Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: Cross-packaging of genetically distinct mouse and primate retroviral RNAs. | Retrovirology BioMed Central Open Access Cross-packaging of genetically distinct mouse and primate retroviral RNAs Noura Salem Al Dhaheri Pretty Susan Phillip Akela Ghazawi Jahabar Ali Elizabeth Beebi Soumeya Ali Jaballah and Tahir A Rizvi Address Department of Microbiology Immunology Faculty of Medicine and Health Sciences FMHS United Arab Emirates University UAEU Al Ain UAE Email Noura Salem Al Dhaheri - 200301922@ Pretty Susan Phillip - prettys@ Akela Ghazawi - akelag@ Jahabar Ali - jahabar@ Elizabeth Beebi - elizabithb@ Soumeya Ali Jaballah - 200770003@ Tahir A Rizvi - tarizvi@ Corresponding author Published 14 July 2009 Received 22 March 2009 Retrovirology 2009 6 66 doi 1742-4690-6-66 Accepted I4 July 2009 This article is available from http content 6 1 66 2009 Al Dhaheri et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The mouse mammary tumor virus MMTV is unique from other retroviruses in having multiple viral promoters which can be regulated by hormones in a tissue specific manner. This unique property has lead to increased interest in studying MMTV replication with the hope of developing MMTV based vectors for human gene therapy. However it has recently been reported that related as well as unrelated retroviruses can cross-package each other s genome raising safety concerns towards the use of candidate retroviral vectors for human gene therapy. Therefore using a trans complementation assay we looked at the ability of MMTV RNA to be cross-packaged and propagated by an unrelated primate Mason-Pfizer monkey virus MPMV that has intracellular assembly process similar to that of MMTV. Results Our .
