Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A CC and CXC chemokine levels in children with meningococcal sepsis accurately predict mortality and disease severity. | Available online http content 10 1 R33 Research CC and CXC chemokine levels in children with meningococcal sepsis accurately predict mortality and disease severity Clementien L Vermont1 2 Jan A Hazelzet1 Ester D de Kleijn1 Germie PJM van den Dobbelsteen2 and Ronald de Groot1 Open Access Department of Pediatrics Erasmus MC-Sophia Children s Hospital Rotterdam The Netherlands 2Netherlands Vaccine Institute Laboratory for Vaccine Development Bilthoven The Netherlands Corresponding author Jan A Hazelzet Received 9 Dec 2005 Revisions requested 16 Jan 2006 Revisions received 26 Jan 2006 Accepted 30 Jan 2006 Published 20 Feb 2006 Critical Care 2006 10 R33 doi cc4836 This article is online at http content 10 1 R33 2006 Vermont et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Chemokines are a superfamily of small peptides involved in leukocyte chemotaxis and in the induction of cytokines in a wide range of infectious diseases. Little is known about their role in meningococcal sepsis in children and their relationship with disease severity and outcome. Methods Monocyte chemoattractant protein MCP -1 macrophage inflammatory protein MIP 1a growth-related gene product GRO -a and interleukin IL -8 were measured in 58 children with meningococcal sepsis or septic shock on admission and 24 hours thereafter. Nine patients died. Serum chemokine levels of survivors and nonsurvivors were compared and the chemokine levels were correlated with prognostic disease severity scores and various laboratory parameters. Results Extremely high levels of all chemokines were measured in the children s acute-phase sera. These levels were significantly higher in nonsurvivors
