Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A Effect of oral decontamination with chlorhexidine on the incidence of nosocomial pneumonia: a meta-analysis | Available online http content 10 1 R35 Research Effect of oral decontamination with chlorhexidine on the incidence of nosocomial pneumonia a meta-analysis Lilibeth A Pineda Ranime G Saliba and Ali A El Solh Open Access Division of Pulmonary Critical Care and Sleep Medicine Department of Medicine University at Buffalo School of Medicine and Biomedical Sciences Buffalo NY USA Corresponding author Ali A El Solh solh@ Received 13 Dec 2005 Revisions requested 16 Jan 2006 Revisions received 25 Jan 2006 Accepted 1 Feb 2006 Published 20 Feb 2006 Critical Care 2006 10 R35 doi cc4837 This article is online at http content 10 1 R35 2006 Pineda et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Nosocomial pneumonia is a significant cause of inhospital morbidity and mortality. Oral care interventions have great potential to reduce the occurrence of nosocomial pneumonia. Studies using topical antiseptic agents yielded mixed results. We hypothesized that the use of chlorhexidine for oral decontamination would reduce the incidence of nosocomial pneumonia in patients requiring mechanical ventilation. Methods This study is a meta-analysis of randomized controlled trials assessing the effect of chlorhexidine on the incidence of nosocomial pneumonia. Data sources were Medline EMBASE Cochrane library citation review of relevant primary and review articles and contact with expert informants. Out of 1 251 articles screened 4 randomized controlled trials were identified that included a total of 1 202 patients. Descriptive and outcome data were extracted by two reviewers independently. Main outcome measures were the incidence of nosocomial pneumonia and mortality. A random effects
