Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-1. | Retrovirology BioMed Central Research Involvement of TORC2 a CREB co-activator in the in vivo-specific transcriptional control of HTLV-1 Shiwen Jiang1 Takefumi Inada2 Masakazu Tanaka1 Rika A Furuta3 Koh Shingu2 and Jun-ichi Fujisawa 1 Address Department of Microbiology Kansai Medical University Moriguchi Osaka 570-8506 Japan 2Department of Anesthesiology Kansai Medical University Moriguchi Osaka 570-8506 Japan and 3Japanese Red Cross Osaka Blood Center Morinomiya Joto-ku Osaka 536-8505 Japan Email Shiwen Jiang - jiangs@ Takefumi Inada - nvkc20988@ Masakazu Tanaka - tanakmas@ Rika A Furuta - furuta@ Koh Shingu - shingu@ Jun-ichi Fujisawa - fujisawa@ Corresponding author Open Access Published II August 2009 Received 31 March 2009 Retrovirology 2009 6 73 doi 1742-4690-6-73 Accepted 1 1 August 2009 This article is available from http content 6 1 73 2009 Jiang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human T-cell leukemia virus type I HTLV-1 causes adult T -cell leukemia ATL but the expression of HTLV-1 is strongly suppressed in the peripheral blood of infected people. However such suppression which may explain the long latency in the development of ATL is readily reversible and viral expression resumes quickly with ex vivo culture of infected T -cells. To investigate the mechanism of in vivo -specific transcriptional suppression we established a mouse model in which mice were intraperitoneally administered syngeneic EL4 T -lymphoma cells transduced with a recombinant retrovirus .
