Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Antithrombin supplementation for anticoagulation during continuous hemofiltration in critically ill patients with septic shock: a case-control study. | Available online http content 10 2 R45 Research Antithrombin supplementation for anticoagulation during continuous hemofiltration in critically ill patients with septic shock a case-control study Damien du Cheyron1 Bruno Bouchet1 Cédric Bruel2 Cédric Daubin1 Michel Ramakers1 and Pierre Charbonneau1 1Medical Intensive Care Unit Caen University Hospital Avenue côte de Nacre 1 4033 Caen cedex France 2Medical Intensive Care Unit Bichat-Claude Bernard University Hospital AP-HP 46 rue Henri Huchard 75018 Paris France Corresponding author Damien du Cheyron ducheyron-d@ Received 21 Oct 2005 Revisions requested 5 Dec 2005 Revisions received 20 Dec 2005 Accepted 13 Feb 2006 Published 13 Mar 2006 Critical Care 2006 10 R45 doi cc4853 This article is online at http content 10 2 R45 2006 du Cheyron et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Acquired antithrombin III AT deficiency may induce heparin resistance and premature membrane clotting during continuous renal replacement therapy CRRT . The purpose of this study was to evaluate the effect of AT supplementation on filter lifespan in critically ill patients with septic shock requiring CRRT. Methods We conducted a retrospective case-control analysis based on a 4-year observational study with prospectively collected data in two medical intensive care units in a university hospital. In all 106 patients with septic shock underwent CRRT during the study period 55 during 2001 to 2002 and 51 during 2003 to 2004 . Of these 78 had acquired AT deficiency plasma level below 70 at onset of renal supportive therapy 40 in the first 2-year period and 38 in the last 2-year period. In the latter intervention period
