Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Activated protein C increases sensitivity to vasoconstriction in rabbit Escherichia coli endotoxin-induced shock. | Available online http content 10 2 R47 Research Activated protein C increases sensitivity to vasoconstriction in rabbit Escherichia coli endotoxin-induced shock Eric Wiel1 2 3 Marion Elizabeth Costecalde1 2 Gilles Lebuffe1 2 Delphine Corseaux4 Brigitte Jude4 Régis Bordet1 Benoit Tavernier1 2 and Benoit Vallet1 2 1EA 1046 Laboratory of Pharmacology University Hospital of Lille France 2Federation of Research in Anesthesiology and Intensive Care Medicine University Hospital of Lille France 3Prehospital Emergency Department SAMU 59 University Hospital of Lille France 4EA 2693-INSERM-ESPRI Laboratory of Hematology University Hospital of Lille France Corresponding author Eric Wiel e-wiel@ Received 12 Dec 2005 Revisions requested 16 Jan 2006 Revisions received 8 Feb 2006 Accepted 20 Feb 2006 Published 15 Mar 2006 Critical Care 2006 10 R47 doi cc4858 This article is online at http content 10 2 R47 2006 Wiel et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The aim of this study was to investigate the effects of activated protein C aPC on vascular function endothelial injury and haemostasis in a rabbit endotoxin-induced shock model. Method This study included 22 male New Zealand rabbits weighing to 3 kg each. In vitro vascular reactivity endothelium CD31-PECAM1 immunohistochemistry plasma coagulation factors and monocyte tissue factor TF expression were performed 5 days D5 after onset of endotoxic shock initiated by mg kg intravenous bolus of Escherichia coli lipopolysaccharide LPS with or without treatment with aPC injected as an intravenous 2 mg kg bolus 1 hour after LPS LPS aPC group and LPS group respectively . Results LPS decreased the .
