Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: Towards a genetic AIDS vaccine. | Retrovirology BioMed Central Commentary Towards a genetic AIDS vaccine Antonia V Bordería and Ben Berkhout Open Access Address Laboratory of Experimental Virology Department of Medical Microbiology Center for Infectious Diseases and Immunology Amsterdam CINIMA Academic Medical Center AMC University of Amsterdam the Netherlands Email Antonia V Bordería - Ben Berkhout - Corresponding author Published 16 October 2009 Received 17 August 2009 Retrovirology 2009 6 93 doi 1742-4690-6-93 Accepted 16 October 2009 This article is available from http content 6 1 93 2009 Bordería and Berkhout licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We discuss a recent Nature Medicine publication by Philip Johnson and co-workers Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat. Med. 2009 15 901-906 in which an effective HIV-1 vaccine was designed that is based on gene therapy. The introduced gene produces an antibody-like immunoadhesin in the blood that neutralizes the virus. Commentary The current status of HIV vaccines The quest for a vaccine against the human immunodeficiency virus type 1 HIV-1 has recently been given a bad prognosis 1 . Most attempts at developing an HIV-1 vaccine have used substances immunogens aimed at stimulating the body s own immune system to produce antibodies or killer T cells that would either neutralize the virus during transmission from one to the other host protective vaccine or control the level of virus replication in an individual who is already infected by HIV-1 therapeutic vaccine . Such traditional HIV vaccines have not elicited protective immune
