Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both . | Retrovirology BioMed Central Research B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env accompanied by increased seroreactivity Tomasz Brudek 1 Tove Christensen1 Lars Aagaard2 Thor Petersen3 Hans J Hansen3 and Anné Moller-Larsen1 Open Access Address Department of Medical Microbiology and Immunology University of Aarhus DK-8000 Aarhus C Denmark 2Department of Molecular Biology University of Aarhus DK-8000 Aarhus C Denmark and 3Department of Neurology University of Aarhus DK-8000 Aarhus C Denmark Email Tomasz Brudek - tb@ Tove Christensen - tc@ Lars Aagaard - laa@ Thor Petersen - thorpete@ Hans J Hansen - hanshans@ Anné Moller-Larsen - aml@ Corresponding author Published 16 November 2009 Received II September 2009 Accepted 16 November 2009 Retrovirology 2009 6 104 doi 1742-4690-6- 104 This article is available from http content 6 1 104 2009 Brudek et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The etiology of the neurogenerative disease multiple sclerosis MS is unknown. The leading hypotheses suggest that MS is the result of exposure of genetically susceptible individuals to certain environmental factor s . Herpesviruses and human endogenous retroviruses HERVs represent potentially important factors in MS development. Herpesviruses can activate HERVs and HERVs are activated in MS patients. Results Using flow cytometry we have analyzed HERV-H Env and HERV-W Env epitope expression on the surface of PBMCs from MS patients with active and stable disease and from control individuals. We have also analyzed serum .
