Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: "Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies. | Retrovirology BioMed Central Open Access Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies Tessa Dieltjens 1 Leo Heyndrickx1 Betty Willems1 Elin Gray2 Lies Van Nieuwenhove3 Katrijn Grupping1 Guido Vanham1 4 and Wouter Janssens1 Address Department of Microbiology Unit of Virology Institute of Tropical Medicine Antwerp Belgium 2National Institute for Communicable Diseases Johannesburg South Africa 3Department of Parasitology Unit of Parasite Diagnostics Institute of Tropical Medicine Antwerp Belgium and 4Department of Biomedical Sciences University of Antwerp Antwerp and Faculty of Medicine and Pharmacy Free University of Brussels Belgium Email Tessa Dieltjens - tdieltjens@ Leo Heyndrickx - lheyndrickx@ Betty Willems - bwillems@ Elin Gray - eling@ Lies Van Nieuwenhove - lvnieuwenhove@ Katrijn Grupping - kgrupping@ Guido Vanham - gvanham@ Wouter Janssens - wouterjanssens@ Corresponding author Published 14 December 2009 Received I September 2009 Accepted 14 December 2009 Retrovirology 2009 6 113 doi 1742-4690-6- 113 This article is available from http content 6 1 1 13 2009 Dieltjens et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A minority of HIV-1 infected individuals develop broad cross-neutralizing BCN plasma antibodies that are capable of neutralizing a spectrum of virus variants belonging to different HIV-1 clades. The aim of this study was to identify the targeted epitopes of an individual with BCN plasma antibodies referred to as ITM4 using peptide phage display. This study also aimed to use the selected mimotopes as tools to unravel the .
