Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion. | Available online http content 10 2 R65 Research A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion Idit Matot1 Carolyn FWeiniger1 Evelyne Zeira2 Eithan Galun2 Bhalchandra V Joshi3 and Kenneth A Jacobson3 Department of Anesthesiology Critical Care Medicine Hadassah University Medical Center The Hebrew University Jerusalem Israel 2Goldyne Savad Institute of Gene Therapy Hadassah University Medical Center The Hebrew University Jerusalem Israel 3Molecular Recognition Section Laboratory of Bioorganic Chemistry National Institute of Diabetes Digestive and Kidney Diseases National Institutes of Health Bethesda Maryland USA Corresponding author Idit Matot iditm@ Received 21 Jan 2006 Revisions requested 2 Mar 2006 Revisions received 6 Mar 2006 Accepted 15 Mar 2006 Published 19 Apr 2006 Critical Care 2006 10 R65 doi cc4893 This article is online at http content 10 2 R65 2006 Matot et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Although activation of A3 adenosine receptors attenuates reperfusion lung injury and associated apoptosis the signaling pathway that mediates this protection remains unclear. Adenosine agonists activate mitogen-activated protein kinases and these kinases have been implicated in ischemia reperfusion injury the purpose of this study was therefore to determine whether A3 adenosine receptor stimulation with reperfusion modulates expression of the different mitogen-activated protein kinases. In addition we compared the effect of the A3 adenosine agonist IB-MECA with the newly synthesized highly selective A3 adenosine receptor agonist MRS3558 on injury in reperfused lung. .
