Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Empiric broad-spectrum antibiotic therapy of nosocomial pneumonia in the intensive care unit: a prospective observational study. | Available online http content 10 3 R78 Open Access Research Empiric broad-spectrum antibiotic therapy of nosocomial pneumonia in the intensive care unit a prospective observational study Francisco Alvarez-Lerma1 Bernabe Alvarez2 Pilar Luque3 Francisco Ruiz4 Jose-Maria Dominguez-Roldan5 Elisabet Quintana6 Cesar Sanz-Rodriguez7 and the ADANN Study Group 1Servicio de Medicina Intensiva Hospital del Mar Barcelona Spain 2Servicio de Medicina Intensiva Hospital General Universitario Alicante Spain 3Servicio de Medicina Intensiva Hospital Clínico Universitario Zaragoza Spain 4Servicio de Medicina Intensiva Complejo Hospitalario de Jaén Spain 5Servicio de Medicina Intensiva Hospital Universitario Virgen del Rocío Sevilla Spain 6Servicio de Medicina Intensiva Hospital de la Santa Creu i Sant Pau Barcelona Spain 7Department of Clinical Research Merck Sharp Dohme of Spain Madrid Spain Corresponding author Francisco Alvarez-Lerma Falvarez@ Received 10 Jan 2006 Revisions requested 16 Feb 2006 Revisions received 11 Apr 2006 Accepted 18 Apr 2006 Published 16 May 2006 Critical Care 2006 10 R78 doi cc4919 This article is online at http content 10 3 R78 2006 Alvarez-Lerma et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Antibiotic de-escalation which consists of the initial institution of empiric broad-spectrum antibiotics followed by antibiotic streamlining driven by microbiological documentation is thought to provide maximum benefit for the individual patient while reducing the selection pressure for resistance. Methods To assess a carbapenem-based de-escalating strategy in nosocomial pneumonia NP a prospective observational study was conducted in critically ill .
