Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: The effect of open lung ventilation on right ventricular and left ventricular function in lung-lavaged pigs. | Available online http content 10 3 R86 Research The effect of open lung ventilation on right ventricular and left ventricular function in lung-lavaged pigs Dinis Reis Miranda1 Lennart Klompe2 Filippo Cademartiri3 Jack J Haitsma1 Alessandro Palumbo3 Johanna JM Takkenberg2 Burkhard Lachmann1 Ad JJC Bogers2 and Diederik Gommers1 Open Access Department of Anesthesiology Erasmus MC Rotterdam The Netherlands department of Cardio-Thoracic Surgery Erasmus MC Rotterdam The Netherlands 3Department of Radiology Erasmus MC Rotterdam The Netherlands Corresponding author Dinis Reis Miranda Received 1 Jan 2006 Revisions requested 15 Feb 2006 Revisions received 18 Apr 2006 Accepted 11 May 2006 Published 8 Jun 2006 Critical Care 2006 10 R86 doi cc4944 This article is online at http content 10 3 R86 2006 Miranda et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by . which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Ventilation according to the open lung concept OLC consists of recruitment maneuvers followed by low tidal volume and high positive end-expiratory pressure aiming at minimizing atelectasis. The minimization of atelectasis reduces the right ventricular RV afterload but the increased intrathoracic pressures used by OLC ventilation could increase the RV afterload. We hypothesize that when atelectasis is minimized by OLC ventilation cardiac function is not affected despite the higher mean airway pressure. Methods After repeated lung lavage each pig n 10 was conventionally ventilated and was ventilated according to OLC in a randomized cross-over setting. Conventional mechanical ventilation CMV consisted of volume-controlled ventilation with 5 cmH2O positive end-expiratory pressure and a tidal volume
