of Internal Medicine, University Hospital Basel, Switzerland Department, Brahms AG, Hennigsdorf, Germany 3Department of Pneumology, University Hospital Basel, Switzerland 4Division of Hospital Epidemiology, Geneva University Hospitals Corresponding author: Mirjam Christ-Crain, christmj@ Received: 25 Apr 2006 Accepted: 22 May 2006 Published: 28 Jun 2006 Critical Care 2006, 10:R96 (doi:) This article is online at: © 2006 Christ-Crain et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the. | Available online http content 10 3 R96 Research Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia ISRCTN04176397 Mirjam Christ-Crain1 Nils G Morgenthaler2 Daiana Stolz3 Christian Muller1 Roland Bingisser1 Stephan Harbarth4 Michael Tamm3 Joachim Struck2 Andreas Bergmann2 and Beat Muller1 Department of Internal Medicine University Hospital Basel Switzerland 2Research Department Brahms AG Hennigsdorf Germany department of Pneumology University Hospital Basel Switzerland 4Division of Hospital Epidemiology Geneva University Hospitals Corresponding author Mirjam Christ-Crain christmj@ Received 25 Apr 2006 Accepted 22 May 2006 Published 28 Jun 2006 Critical Care 2006 10 R96 doi cc4955 This article is online at http content 10 3 R96 2006 Christ-Crain et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Pro-adrenomedullin proADM is helpful for individual risk assessment and outcome prediction in sepsis. A major cause of sepsis is community-acquired pneumonia CAP . The aim of this study was to investigate the value of proADM levels for severity assessment and outcome prediction in CAP. Methods Data from 302 patients admitted to the emergency department with CAP were included in a prospective observational study. Procalcitonin C-reactive protein levels leukocyte count clinical variables and the pneumonia severity index PSI were measured. ProADM levels were measured with a new sandwich immunoassay for mid regional ProADM MR-proADM Brahms AG Hennigsdorf Berlin Germany . Results ProADM levels in contrast to C-reactive protein and leukocyte count increased with increasing severity of CAP classified according to the PSI score .
