Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion. | Bourry et al. Retrovirology 2010 7 78 http content 7 1 78 RETROVIROLOGY RESEARCH Open Access Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion I ỉV Ỉ ZM D I I r z 4 5 A I l r I h I s I f I 11 1 4 c -J I i - r1 2 4 I I I D I I r I V r 12 I I I r I f I I K S Z 1 f s r r S-. I I 3 Olivier Bourry AbdeiKrim iviannioui Pierre seiiier Camille Roucairoi Lucie Durand-Gasseiin Nathalie Dereuddre-Bosquet1 4 Henri Benech3 Pierre Roques1 4 Roger Le Grand1 4 Abstract Background HIV reservoirs are rapidly established after infection and the effect of HAART initiated very early during acute infection on HIV reservoirs remains poorly documented particularly in tissue Known to actively replicate the virus. In this context we used the model of experimental infection of macaques with pathogenic SIV to assess in different tissues i the effect of a short term HAART initiated at different stages during acute infection on viral dissemination and replication and ii the local concentration of antiviral drugs. Results Here we show that early treatment with AZT 3TC IDV initiated either within 4 hours after intravenous infection of macaques with SIVmac251 as a post exposure prophylaxis or before viremia peak 7 days postinfection pi had a strong impact on SIV production and dissemination in all tissues but did not prevent infection. When treatment was initiated after the viremia peak 14 days pi or during early chronic infection 150 days pi significant viral replication persists in the peripheral lymph nodes and the spleen of treated macaques despite a strong effect of treatment on viremia and gut associated lymphoid tissues. In these animals the level of virus persistence in tissues was inversely correlated with local concentrations of 3TC high concentrations of 3TC were measured in the gut whereas low concentrations were observed in the secondary lymphoid tissues. IDV like 3TC showed much higher .
