Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Decidual soluble factors participate in the control of HIV-1 infection at the . | RETROVIROLOGY Decidual soluble factors participate in the control of HIV-1 infection at the maternofetal interface Marlin et al. Marlin et al. Retrovirology 2011 8 58 http content 8 1 58 18 July 2011 2 BioMed Central Marlin et al. Retrovirology 2011 8 58 http content 8 1 58 RETR0VIR0L0GY RESEARCH Open Access Decidual soluble factors participate in the control of HIV-1 infection at the maternofetal interface 11 11 1 1 2 3 Romain Marlin Marie-Thérèse Nugeyre Marion Duriez Claude Cannou Anne Le Breton Nadia Berkane Frangoise Barré-Sinoussi1 and Elisabeth Menu1 Abstract Background Maternofetal transmission MFT of HIV-1 is relatively rare during the first trimester of pregnancy despite the permissivity of placental cells for cell-to-cell HIV-1 infection. Invasive placental cells interact directly with decidual cells of the uterine mucosa during the first months of pregnancy but the role of the decidua in the control of HIV-1 transmission is unknown. Results We found that decidual mononuclear cells naturally produce low levels of IL-10 IL-12 IL-15 TNF-a IFN-a IFN-g and CXCL-12 SDF-1 and large amounts of CCL-2 MCP1 CCL-3 MIP-1a CCL-4 MIP-1P CCL-5 Rantes CXCL-10 IP-10 IL-6 and IL-8. CCL-3 and CCL-4 levels were significantly upregulated by in vitro infection with R5 HIV-1 but not X4. Decidual CD14 antigen presenting cells were the main CCL-3 and CCL-4 producers among decidual leukocytes. R5 and X4 HIV-1 infection was inhibited by decidual cell culture supernatants in vitro. Using HIV-1 pseudotypes we found that inhibition of the HIV-1 entry step was inhibited by decidual soluble factors. Conclusion Our findings show that decidual innate immunity soluble factors is involved in the control of HIV-1 infection at the maternofetal interface. The decidua could thus serve as a mucosal model for identifying correlates of protection against HIV-1 infection. Background Cytokines are involved in cell activation immune response polarization .
