Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes. | Bayer et al. Retrovirology 2011 8 75 http content 8 1 75 RETR0VIR0L0GY RESEARCH Open Access Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes f 1 f 1 1 1 Wibke Bayer Ruth Lietz Teona Ontikatze Lena Johrden Matthias Tenbusch Ghulam Nabi c I m Z c z I m m z kr2D F r m r I I4 5 I_I f- A Z I f4 r r zd z IV A D M r I6 ị I I I r I I 1 Z z I 1 I I I f I F m z r2f s zd Simone schimmer Peter Groitl nans woit Cassandra M Berry Klaus Uberia Ulf Dittmer and Oliver Wildner1 7f Abstract Background Type I interferons IFNs exhibit direct antiviral effects but also distinct immunomodulatory properties. In this study we analyzed type I IFN subtypes Tor their effect on prophylactic adenovirus-based antiretroviral vaccination oT mice against Friend retrovirus FV or HIV. Results Mice were vaccinated with adenoviral vectors encoding FV Env and Gag proteins alone or in combination with vectors encoding IFNa1 IFNa2 IFNa4 IFNa5 IFNa6 IFNa9 or IFNp. Only the co-administration oT adenoviral vectors encoding IFNa2 IFNa4 IFNa6 and IFNa9 resulted in strongly improved immune protection oT vaccinated mice Trom subsequent FV challenge infection with high control over FV-induced splenomegaly and reduced viral loads. The level oT protection correlated with augmented virus-speciTic CD4 T cell responses and enhanced antibody titers. Similar results were obtained when mice were vaccinated against HIV with adenoviral vectors encoding HIV Env and Gag-Pol in combination with various type I IFN encoding vectors. Here mainly CD4 T cell responses were enhanced by IFNa subtypes. Conclusions Our results indicate that certain IFNa subtypes have the potential to improve the protective effect oT adenovirus-based vaccines against retroviruses. This correlated with augmented virus-speciTic CD4 T cell and antibody responses. Thus co-expression oT select type I IFNs may be a .
