Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats. | Available online http content 10 4 R117 Research Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats Jurgen Birnbaum1 Edda Klotz1 Claudia D Spies1 Bjorn Lorenz1 Patrick Stuebs1 Ortrud Vargas Hein1 Matthias Grundling2 Dragan Pavlovic2 Taras Usichenko2 Michael Wendt2 Wolfgang J Kox1 and Christian Lehmann2 Department of Anesthesiology and Intensive Care Medicine Campus Charité Mitte and Campus Virchow Klinikum Charité-University Medicine Berlin Charitéplatz 1 10117 Berlin Germany department of Anesthesiology and Intensive Care Medicine Ernst-Moritz-Arndt-University Greifswald Friedrich Loffler-Str. 23 B 17475 Greifswald Germany Corresponding author Jurgen Birnbaum Received 16 Feb 2006 Revisions requested 31 Mar 2006 Revisions received 19 Jul 2006 Accepted 7 Aug 2006 Published 7 Aug 2006 Critical Care 2006 10 R117 doi cc5011 This article is online at http content 10 4 R117 2006 Birnbaum et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Dopexamine may be a therapeutic option to improve hepatosplanchnic perfusion in sepsis. To investigate this possibility we administered dopexamine in an experimental sepsis model in rats. Methods This prospective randomized controlled laboratory study was conducted in 42 Wistar rats. The animals were divided into three groups. Group 1 served as the control group CON group . The animals in both groups 2 LPS group and 3 DPX group received an endotoxin lipopolysaccharide from Escherichia coli - LPS infusion 20 mg kg for 15 minutes . DPX group additionally received dopexamine pg kg per minute over four hours . One half of the animals in
