Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury. | Available online http content 10 5 R126 Research Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury Magda Cepkova Sandra Brady Anil Sapru Michael A Matthay and Gwynne Church The Cardiovascular Research Institute and the Departments of Medicine and Anesthesia University of California San Francisco 505 Parnassus Avenue M917 San Francisco CA 94143-0624 USA Corresponding author Michael A Matthay Received 20 Jun 2006 Revisions requested 20 Jul 2006 Revisions received 14 Aug 2006 Accepted 6 Sep 2006 Published 6 Sep 2006 Critical Care 2006 10 R126 doi cc5037 This article is online at http content 10 5 R1 26 2006 Cepkova et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Background Several biological markers of lung injury are predictors of morbidity and mortality in patients with acute lung injury ALI . The low tidal volume lung-protective ventilation strategy is associated with a significant decrease in plasma biomarker levels compared to the high tidal volume ventilation strategy. The primary objective of this study was to test whether the institution of lung-protective positive pressure ventilation in spontaneously ventilating patients with ALI exacerbates preexisting lung injury by using measurements of biomarkers of lung injury before and after intubation. Materials and methods A prospective observational cohort study was conducted in the intensive care unit of a tertiary care university hospital. Twenty-five intubated mechanically ventilated patients with ALI were enrolled. Physiologic data and serum samples were collected within 6 hours before intubation and at
