Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction. | Available online http content 10 5 R136 Research Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction D Shane O Mahony1 2 W Conrad Liles3 William A Altemeier1 Shireesha Dhanireddy3 Charles W Frevert1 2 Denny Liggitt4 Thomas R Martin1 2 and Gustavo Matute-Bello1 2 1 Division of Pulmonary and Critical Care Medicine University of Washington School of Medicine Seattle WA 98195 2Medical Research Service VA Puget Sound Health Care System 1660 S. Columbian Way Seattle WA 98108 3Division of Allergy and Infectious Diseases University of Washington School of Medicine Seattle WA 98195 4Department of Comparative Medicine University of Washington School of Medicine Seattle WA 9815 Corresponding author Gustavo Matute-Bello matuteb@ Received 11 Apr 2006 Revisions requested 16 May 2006 Revisions received 9 Sep 2006 Accepted 22 Sep 2006 Published 22 Sep 2006 Critical Care 2006 10 R136 doi cc5050 This article is online at http content 10 5 R136 2006 O Mahony et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Multiple organ dysfunction syndrome MODS is a common complication of sepsis in mechanically ventilated patients with acute respiratory distress syndrome but the links between mechanical ventilation and MODS are unclear. Our goal was to determine whether a minimally injurious mechanical ventilation strategy synergizes with low-dose endotoxemia to induce the activation of pro-inflammatory pathways in the lungs and in the systemic circulation resulting in distal organ dysfunction and or injury. Methods We administered intraperitoneal Escherichia coli lipopolysaccharide LPS 1 pg g to C57BL 6 mice and 14 hours later .
