Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Iatrogenesis, inflammation and organ injury: insights from a murine model. | Available online http content 10 6 173 Commentary Iatrogenesis inflammation and organ injury insights from a murine model John C Marshall Professor of Surgery University of Toronto St Michael s Hospital 30 Bond St Rm 4-007 Bond Wing Toronto Ontario Canada M5B 1W8 Correspondence John C Marshall marshallj@ Published 17 November 2006 This article is online at http content 10 6 173 2006 BioMed Central Ltd Critical Care 2006 10 173 doi cc5087 See related research by O Mahony et al. http content 10 5 R136 Abstract The complex biology of critical illness not only reflects the initial insult that brought the patient to the intensive care unit but also and perhaps even more importantly it reflects the consequences of the many clinical interventions initiated to support life during a time of lethal organ system insufficiency. The latter may amplify or modify the response to the former and are eminently amenable to modulation by changes in practice. However they rarely figure in conceptual models of critical illness and are almost never accounted for in preclinical models of disease. In the preceding issue of Critical Care O Mahony and colleagues reported on an animal model in which sequential insults - low-dose endotoxin followed by mechanical ventilation - induce much greater remote organ injury than either insult alone. Although animal models are poor surrogates for clinical illness studies such as these provide valuable platforms for probing the complex interactions between insult and therapy that give rise to the intricate biology of critical illness. The multiple organ dysfunction syndrome - the common final pathway to death for the majority of eritieally ill patients who succumb in the intensive care unit - is an enormously complex and elusive process. Support of acute organ system insufficiency is the raison d etre of intensive care and is the embodiment of the remarkable successes of a relatively young .
