Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: High-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. | Available online http content 10 6 240 Review Bench-to-bedside review High-frequency oscillatory ventilation in adults with acute respiratory distress syndrome James Downar1 and Sangeeta Mehta1 2 1 Department of Medicine Mount Sinai Hospital and University of Toronto 600 University Avenue 18-216 Toronto Ontario Canada interdepartmental Division of Critical Care Medicine Mount Sinai Hospital and University of Toronto 600 University Avenue 18-216 Toronto Ontario Canada Corresponding author Sangeeta Mehta Published 13 December 2006 This article is online at http content 10 6 240 2006 BioMed Central Ltd Critical Care 2006 10 240 doi cc5096 Abstract Mechanical ventilation is the cornerstone of therapy for patients with acute respiratory distress syndrome ARDS . Paradoxically mechanical ventilation can exacerbate lung damage - a phenomenon known as ventilator-induced lung injury. While new ventilation strategies have reduced the mortality rate in patients with ARDS this mortality rate still remains high. High-frequency oscillatory ventilation HFOV is an unconventional form of ventilation that may improve oxygenation in patients with ARDS while limiting further lung injury associated with high ventilatory pressures and volumes delivered during conventional ventilation. HFOV has been used for almost two decades in the neonatal population but there is more limited experience with HFOV in the adult population. In adults the majority of the published literature is in the form of small observational studies in which HFOV was used as rescue therapy for patients with very severe ARDS who were failing conventional ventilation. Two prospective randomized controlled trials however while showing no mortality benefit have suggested that HFOV compared with conventional ventilation is a safe and effective ventilation strategy for adults with ARDS. Several studies suggest that HFOV may improve outcomes if used early in the course .
