Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Seleno-enzymes and seleno-compounds: the two faces of selenium Xavier Forceville. | Available online http content 10 6 180 Commentary Seleno-enzymes and seleno-compounds the two faces of selenium Xavier Forceville Ch Meaux Réanimation Polyvalente 6-8 rue Saint Fiacre 77104 Meaux France Corresponding author Xavier Forceville xforceville@ Published 13 December 2006 This article is online at http content 10 6 180 2006 BioMed Central Ltd Critical Care 2006 10 180 doi cc5109 See related research by Berger et al. http content 10 5 R153 Abstract Selenium protects cells and inhibits many inflammatory cell mechanisms through antioxidant seleno-enzymes. Immunity improvement is illustrated by the study of Berger and colleagues with reduction of nosocomial pneumonia in burnt patients under multitrace-element supplementation. As seleno-compounds especially sodium selenite are pro-oxidant however administration above 800 pg day may be dangerous in septic shock. Paradoxically direct reversible pro-oxidative effects of seleno-compounds may also be beneficial for reduction of inflammation genomic action apoptosis and may even be bactericidal or virucidal. These facts need to be further examined as well as the possible dramatic drop of plasma selenoprotein P in septic shock and its role in endothelium protection. Biological and medical advances in the area of selenium provide interest in selenium for both its antioxidant properties through seleno-enzyme incorporation as illustrated in the previous issue of Critical Care 1 and its direct pro-oxidant toxic effect through seleno-compounds. In intensive care and especially in septic shock adjunctive therapy there is a growing interest in the antioxidant role of selenium 2-5 . We know that there is a very low level of selenium in the human 20 mg for the whole body but that a severe deficiency is lethal 6 . We also know that selenium plays a crucial role in antioxidant defense as one selenium atom is absolutely required at the active site of all selenoenzymes in the .
