Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death. | Available online http content 10 6 427 Letter Drotrecogin alfa activated in patients with severe sepsis and a high risk of death Jan O Friedrich1 Neill KJ Adhikari2 and Maureen O Meade3 Critical Care and Medicine Departments St. Michael s Hospital Interdepartmental Division of Critical Care University of Toronto Bond Street Toronto Ontario Canada M5B 1W8 2Department of Critical Care Medicine Sunnybrook Health Sciences Centre Interdepartmental Division of Critical Care University of Toronto Bayview Avenue Toronto Ontario Canada M4N 3M5 3Departments of Medicine and Clinical Epidemiology Biostatistics McMaster University Department of Critical Care Hamilton Health Sciences Main Street West Hamilton Ontario Canada L8N 3Z5 Correspondence Jan O Friedrich Published 20 December 2006 This article is online at http content 10 6 427 2006 BioMed Central Ltd Critical Care 2006 10 427 doi cc5117 See related letter by Williams et al. http content 10 5 424 letter by Friedrich et al. http content 10 5 420 letter by Agarwal and Nath http content 10 4 416 and commentary by Friedrich et al. http content 10 3 145 We are pleased that Williams and coworkers 1 confirmed our random effects analysis 2 which relied on publicly available data. This analysis pooled the results from patients with Acute Physiology and Chronic Health Evaluation APACHE II scores of 25 or greater from the PROWESS Recombinant Human Activated Protein C Worldwide Evaluation of Severe Sepsis 3 and ADDRESS Administration of Drotrecogin Alfa Activated in Early Stage Severe Sepsis 4 trials. As we discussed previously 5 this analysis demonstrates a surprising degree of statistical heterogeneity which remains despite minimal methodologic differences between the two trials and further minimization of clinical heterogeneity by selecting a more uniform subgroup of patients with severe sepsis and a high risk for death. This .
