Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Due caution using early β-blockers for acute myocardial infarction. | This article is online at http content 11 1 301 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique Due caution using early p-blockers for acute myocardial infarction Scott McKee 1 Holt Murray 2 and John A. Kellum3 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Visiting Instructor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 3 Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 25 January 2007 This article is online at http content 11 1 301 2006 BioMed Central Ltd Critical Care 2006 11 301 DOI 101186 cc5145 Expanded Abstract Citation Chen ZM Pan HC Chen YP Peto R Collins R Jiang LX Xie JX Liu LS. Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction randomised placebo-controlled trial. Lancet 2005 366 1622-1632 1 . Background Despite previous randomised trials of early p-blocker therapy in the emergency treatment of myocardial infarction MI uncertainty has persisted about the value of adding it to current standard interventions . aspirin and fibrinolytic therapy and the balance of potential benefits and hazards is still unclear in high-risk patients. Methods Design and setting Prospective blinded randomized controlled trial in 1250 hospitals in China. Subjects 45 852 patients admitted within 24 h of suspected acute MI onset. 93 had ST-segment elevation or bundle branch block and 7 had ST-segment depression. Intervention Subjects were randomly allocated metoprolol up to 15 mg intravenous then 200 mg oral daily n 22 929 or matching placebo n 22 923 . Treatment was to continue until discharge or up to 4 weeks in hospital mean 15 days in survivors and 89 .
