Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Recently published papers: the Jekyll and Hyde of oxygen, neuromuscular blockade and good vibrations? | Available online http content 11 1 108 Commentary Recently published papers the Jekyll and Hyde of oxygen neuromuscular blockade and good vibrations Jonathan Ball General Intensive Care Unit St George s Hospital Blackshaw Road London SW17 0QT UK Corresponding author Jonathan Ball jball@ Published 12 February 2007 This article is online at http content 11 1 108 2007 BioMed Central Ltd Critical Care 2007 11 108 doi cc5160 Abstract This issue s recently published papers commentary takes a long hard look at the surprisingly topically issue of oxygen. To give a balanced perspective topical ventilatory studies are also discussed. Confused by oxygen Several recently published papers have demonstrated both the pros and cons of oxygen therapy. They also serve to illustrate that extrapolating from studies with experimental animal models to the clinical arena requires great caution. In a rat model of haemorrhagic shock Brod and colleagues investigated the effects of combined resuscitation with hypertonic saline and oxygen 1 . The authors designed a complex protocol with sequential single interventions and compared 5 ml kg fluid resuscitation using and saline and a fraction of inspired oxygen FiO2 of and . They measured regional perfusion in several vascular beds together with plasma lactate as a measure of the adequacy of resuscitation. Their results showed that saline and 100 oxygen was the superior strategy. Of particular note were the marked haemodynamic effects of increasing the FiO2 to . The accompanying editorial 2 considers these results in a wider clinical context. It rightly concludes that the effects of 100 oxygen on regional blood flow and hence its role in resuscitation have for too long been neglected and warrant further investigation. Multiple organ failure syndrome MOFS is the final common pathway of critical illness. Imperatore and colleagues have previously demonstrated that intermittent .
