Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Searching for non-invasive markers of tissue hypoxia. | Available online http content 11 1 116 Commentary Searching for non-invasive markers of tissue hypoxia Juan Carlos Puyana1 and Michael R Pinsky2 Associate Professor of Surgery and Critical Care Director Applied Research IMITs Center Innovative Medical Information Technology Center UPMC F1265 Presbyterian 200 Lothrop Street Pittsburgh PA 15213-2536 USA 2Professor of Critical Care Medicine Bioengineering and Anesthesiology 606 Scaife Hall 3550 Terrace Street Pittsburgh PA 15261 USA Corresponding author Michael R Pinsky pinskymr@ Published 23 February 2007 This article is online at http content 11 1 116 2007 BioMed Central Ltd Critical Care 2007 11 116 doi cc5691 See related research by Podbregar and Mozina http content 11 1 R6 Abstract Tissue hypoxia is a common end product of circulatory shock and a primary target for resuscitation efforts. In this issue Podbregar and Mozina show that thenar tissue O2 saturation StO2 and mixed venous O2 saturation SvO2 co-vary in patients in left ventricular failure but in patients with sepsis StO2 was higher than SvO2. Although StO2 may co-vary with SvO2 they have different determinants such that after shock StO2 may increase well before SvO2 as a result of increased O2 demands to repay O2 debt incurred during hypoperfusion. Thus the use of StO2 alone to define the endpoint of resuscitation may be misleading. In this issue of the journal Podbregar and Mozina propose the use of tissue oxygen saturation StO2 monitored non-invasively with near-infrared spectroscopy of the thenar muscle as a surrogate measurement of tissue perfusion 1 . They measured StO2 in patients with left ventricular LV failure and with or without sepsis. They reasoned that StO2 would discriminate between patients with low cardiac output and preserved or unimpaired O2 extraction ratio not present in septic patients from those septic patients with poor ventricular function and low O2 extraction ratio as assessed .
