Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability. | Available online http content 11 1 R20 Research Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability Jeffrey M Halter1 Jay M Steinberg1 Louis A Gatto2 Joseph D DiRocco1 Lucio A Pavone1 Henry J Schiller3 Scott Albert1 Hsi-Ming Lee4 David Carney5 and Gary F Nieman1 Department of Surgery SUNY Upstate Medical University E Adams St Syracuse New York 13210 USA department of Biological Sciences SUNY Cortland Graham Avenue Cortland New York 13045 USA department of Surgery Mayo Clinic 1st Street SW Rochester Minnesota 55905 USA department of Oral Biology and Pathology SUNY Stonybrook School of Dental Medicine - South Campus Stonybrook New York 11794 USA 5Savannah Pediatric Surgery Department Memorial Health University Medical Center Waters Avenue Savannah Georgia 31404 USA Corresponding author Gary F Nieman niemang@ Received 2 Oct 2006 Revisions requested 25 Oct 2006 Revisions received 24 Jan 2007 Accepted 15 Feb 2007 Published 15 Feb 2007 Critical Care 2007 11 R20 doi cc5695 This article is online at http content 11 1 R20 2007 Halter et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction One potential mechanism of ventilator-induced lung injury VILI is due to shear stresses associated with alveolar instability reeruitment dereeruitment . It has been postulated that the optimal combination of tidal volume Vt and positive end-expiratory pressure PEEP stabilizes alveoli thus diminishing recruitment derecruitment and reducing VILI. In this study we directly visualized the effect of Vt and PEEP on alveolar mechanics and correlated alveolar stability with lung injury. Methods In vivo microscopy was utilized .
