Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study. | Available online http content 11 1 R29 Research Meperidine and skin surface warming additively reduce the shivering threshold a volunteer study Oliver Kimberger1 Syed Z Ali1 Monica Markstaller1 Sandra Zmoos1 Rolf Lauber1 Corinne Hunkeler1 and Andrea Kurz1 2 Department of Anaesthesiology University of Bern CH-3010 Bern Switzerland 2Outcomes Research Institute University of Louisville 2301 S 3RD St Louisville KY 40292-2001 USA Corresponding author Oliver Kimberger study@ Received 6 Dec 2006 Revisions requested 30 Jan 2007 Revisions received 12 Feb 2007 Accepted 23 Feb 2007 Published 23 Feb 2007 Critical Care 2007 11 R29 doi cc5709 This article is online at http content 11 1 R29 2007 Kimberger et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Mild therapeutic hypothermia has been shown to improve outcome for patients after cardiac arrest and may be beneficial for ischaemic stroke and myocardial ischaemia patients. However in the awake patient even a small decrease of core temperature provokes vigorous autonomic reactions-vasoconstriction and shivering-which both inhibit efficient core cooling. Meperidine and skin warming each linearly lower vasoconstriction and shivering thresholds. We tested whether a combination of skin warming and a medium dose of meperidine additively would reduce the shivering threshold to below 34 C without producing significant sedation or respiratory depression. Methods Eight healthy volunteers participated on four study days 1 control 2 skin warming with forced air and warming mattress 3 meperidine target plasma level ựg ml and 4 skin warming plus meperidine target plasma level ựg ml . Volunteers were cooled .
