Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Beneficial effects of erythropoietin in preclinical models of shock and organ failure. | Available online http content 11 3 132 Commentary Beneficial effects of erythropoietin in preclinical models of shock and organ failure Christoph Thiemermann Centre Lead for Translational Medicine Therapeutics The William Harvey Research Institute Queen Mary - University of London Barts and The London School of Medicine and Dentistry Charterhouse Square London EC1M 6BQ UK Corresponding author Christoph Thiemermann Published 29 May 2007 This article is online at http content 11 3 132 2007 BioMed Central Ltd Critical Care 2007 11 132 doi cc5912 See related research by Kao et al. http content 11 3 R58 Abstract Erythropoietin protects many organs against the tissue injury and dysfunction caused by ischaemia reperfusion and excessive inflammation. This editorial comment discusses the effects of erythropoietin in preclinical models of septic shock endotoxemia hemorrhagic shock spinal cord trauma and zymosan-induced multiple organ failure. Erythropoietin EPO is a 34 kDa glycoprotein hormone that controls the proliferation differentiation and survival of erythroid progenitor cells through an antiapoptotic mechanism. It has become apparent that EPO protects many organs including brain heart kidney and liver against the injury caused by ischaemia reperfusion hemorrhagic shock and systemic inflammation. In this issue of Critical Care Kao and colleagues 1 report their findings in an established murine model of polymicrobial sepsis. They found that recombinant human EPO 400 IU kg exerts significant beneficial effects when it is given as late as 18 hours after caecal ligation and puncture CLP . Although EPO had no effect on the small decline in blood pressure the decline in platelet and white blood cell counts or the rise in lactate it significantly increased tissue perfusion and reduced tissue hypoxia. Within 18 hours after CLP there was a decline in the number of perfused capillary beds reduced oxygen .
