Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. | Available online http content 11 3 R56 Open Access Research Effect of induction agent on vasopressor and steroid use and outcome in patients with septic shock David Charles Ray and Dermot William McKeown Department of Anaesthesia Critical Care Pain Medicine Royal Infirmary of Edinburgh Little France Crescent Edinburgh EH1 6 4SA Scotland UK Corresponding author David Charles Ray Received 22 Feb 2007 Revisions requested 21 Mar 2007 Revisions received 11 Apr 2007 Accepted 16 May 2007 Published 16 May 2007 Critical Care 2007 11 R56 doi cc5916 This article is online at http content 11 3 R56 2007 Ray and McKeown licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction In seriously ill patients etomidate gives cardiovascular stability at induction of anaesthesia but there is concern over possible adrenal suppression. Etomidate could reduce steroid synthesis and increase the need for vasopressor and steroid therapy. The outcome could be worse than in patients given other induction agents. Methods We reviewed 159 septic shock patients admitted to our intensive care unit ICU over a 40-month period to study the association between induction agent and clinical outcome including vasopressor inotrope and steroid therapy. From our records we retrieved induction agent use vasopressor administration at induction vasopressor inotrope and steroid administration in the ICU and hospital outcome. Results Hospital mortality was 65 . The numbers of patients given an induction agent were 74 etomidate 25 propofol 26 thiopental 18 other agent and 16 no agent. Vasopressor inotrope or steroid administration and outcome were not related to the induction agent chosen. Corticosteroid
