Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model. | Available online http content 11 3 R58 Research Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model Raymond Kao1 2 Anargyros Xenocostas2 Tao Rui2 Pei Yu2 Weixiong Huang2 James Rose2 and Claudio M Martin2 Department of National Defense Canadian Forces Medical Group 1745 Alta Vista Drive Ottawa Ontario K1A 0K6 Canada 2London Health Sciences Center Divisions of Critical Care Hematology Center for Critical Illness Research Lawson Health Research Institute University of Western Ontario 800 Commissioner s Rd. E. London Ontario N6A 5W9 Canada Corresponding author Raymond Kao rkao3@ Received 30 Jan 2007 Revisions requested 27 Feb 2007 Revisions received 17 Apr 2007 Accepted 18 May 2007 Published 18 May 2007 Critical Care 2007 11 R58 doi cc5920 This article is online at http content 11 3 R58 2007 Kao et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The relationship between oxygen delivery and consumption in sepsis is impaired suggesting a microcirculatory perfusion defect. Recombinant human erythropoietin rHuEPO regulates erythropoiesis and also exerts complex actions promoting the maintenance of homeostasis of the organism under stress. The objective of this study was to test the hypothesis that rHuEPO could improve skeletal muscle capillary perfusion and tissue oxygenation in sepsis. Methods Septic mice in three experiments received rHu-EPO 400 U kg subcutaneously 18 hours after cecal ligation and perforation CLP . The first experiment measured the acute effects of rHuEPO on hemodynamics blood counts and arterial lactate level. The next two sets of experiments used intravital microscopy to observe .
