Retrovirology Research BioMed Central Open Access HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4 Isabel Puigdomènech1, Marta Massanella1, Nuria Izquierdo-Useros1, Raul Ruiz-Hernandez1, Marta Curriu1, Margarita Bofill1,2, Javier MartinezPicado1,2, Manel Juan3,4, Bonaventura Clotet1 and Julià Blanco*1 Address: 1Fundació irsiCaixa, Institut de Recerca en Ciències de la Salut Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona 08916, Barcelona, Catalonia, Spain, 2ICREA, Fundació irsiCaixa, Hospital Germans Trias i Pujol, Badalona 08916 Barcelona, Catalonia, Spain, 3LIRAD, Institut de Recerca en Ciències de la Salut Germans Trias. | Retrovirology BioMed Central Research HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4 Isabel Puigdomènech1 Marta Massanella1 Nuria Izquierdo-Useros1 Raul Ruiz-Hernandez1 Marta Curriu1 Margarita Bofill1 2 Javier Martinez-Picado1 2 Manel Juan3 4 Bonaventura Clotet1 and Julia Blanco 1 Open Access Address 1Fundació irsiCaixa Institut de Recerca en Ciències de la Salut Germans Trias i Pujol IGTP Hospital Germans Trias i Pujol Universitat Autònoma de Barcelona Badalona 08916 Barcelona Catalonia Spain 2ICREA Fundació irsiCaixa Hospital Germans Trias i Pujol Badalona 08916 Barcelona Catalonia Spain 3LIRAD Institut de Recerca en Ciències de la Salut Germans Trias i Pujol IGTP Hospital Germans Trias i Pujol Universitat Autònoma de Barcelona Badalona 08916 Barcelona Catalonia Spain and 4Servei d Immunologia. CDB - Hospital Clinic Villaroel 170 08036 Barcelona Spain Email Isabel Puigdomènech - ipuig@ Marta Massanella - mmassanellla@ Nuria Izquierdo-Useros - nizquierdo@ Raul Ruiz-Hernandez - rruiz@ Marta Curriu - mcurriu@ Margarita Bofill - mbofill@ Javier Martinez-Picado - jmpicado@ Manel Juan - mjuan@ Bonaventura Clotet-bclotet@ Julia Blanco - jblanco@ Corresponding author Published 31 March 2008 Received 10 January 2008 Accepted 31 March 2008 Retrovirology 2008 5 32 doi l 742-4690-5-32 This article is available from http content 5 1 32 2008 Puigdomènech et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cell-to-cell HIV transmission requires cellular contacts that .
