Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Uracil within DNA: an actor of antiviral immunity. | Retrovirology BioMed Central Open Access Uracil within DNA an actor of antiviral immunity Josephine Sire1 Gilles Quérat1 Cécile Esnault2 and Stéphane Priet 3 Address 1UMR IRD-190 Emergence des Pathologies Virales Faculté de Médecine 27 Bd Jean Moulin 13005 Marseille France 2Unité des Retrovirus Endogènes et Eléments Rétroides des Eucaryotes Supérieurs UMR 8122 CNRS Institut Gustave Roussy 94805 Villejuif France and 3Architecture et Fonction des Macromolécules Biologiques CNRS UMR 6098 ESIL case 925 13288 Marseille Cedex 9 France Email Joséphine Sire - jsire@ Gilles Quérat - gquerat@ Cécile Esnault - cesnault@ Stéphane Priet - Corresponding author Published 5 June 2008 Received 13 February 2008 Retrovirology 2008 5 45 doi 1742-4690-5-45 Accepted 5 June 2008 This article is available from http content 5 1 45 2008 Sire et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Uracil is a natural base of RNA but may appear in DNA through two different pathways including cytosine deamination or misincorporation of deoxyuridine 5 -triphosphate nucleotide dUTP during DNA replication and constitutes one of the most frequent DNA lesions. In cellular organisms such lesions are faithfully cleared out through several universal DNA repair mechanisms thus preventing genome injury. However several recent studies have brought some pieces of evidence that introduction of uracil bases in viral genomic DNA intermediates during genome replication might be a way of innate immune defence against some viruses. As part of countermeasures numerous viruses have .
