Báo cáo y học: "Oral keratinocytes support non-replicative infection and transfer of harbored HIV-1 to permissive cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Oral keratinocytes support non-replicative infection and transfer of harbored HIV-1 to permissive cells. | Retrovirology BioMed Central Research Oral keratinocytes support non-replicative infection and transfer of harbored HIV-I to permissive cells Anjalee Vacharaksa 1 2 Anil C Asrani1 2 Kristin H Gebhard1 2 Claudine E Fasching2 Rodrigo A Giacaman1 2 Edward N Janoff2 3 Karen F Ross1 2 and Mark C Herzberg 1 2 Open Access Address Department of Diagnostic and Biological Sciences School of Dentistry University of Minnesota Minneapolis MN 55455 USA 2Mucosal and Vaccine Research Center Minneapolis VA Medical Center Minneapolis MN 55417 USA and 3Division of Infectious Diseases Colorado Center for AIDS Research and the Mucosal and Vaccine Research Program Colorado University of Colorado Denver and the Denver Veterans Affairs Medical Center Denver CO 80220 USA Email Anjalee Vacharaksa - tang0160@ Anil C Asrani - asran003@ Kristin H Gebhard - kristingebhard@ Claudine E Fasching - Rodrigo A Giacaman - giac0015@ Edward N Karen F Ross - rossx007@ Mark C Herzberg - mcherzb@ Corresponding author Published 17 July 2008 Received 30 April 2008 Retrovirology 2008 5 66 doi 1742-4690-5-66 Accepted I7 July 2008 This article is available from http content 5 1 66 2008 Vacharaksa et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Oral keratinocytes on the mucosal surface are frequently exposed to HIV-1 through contact with infected sexual partners or nursing mothers. To determine the plausibility that oral keratinocytes are primary targets of HIV-1 we tested the hypothesis that HIV-1 infects oral keratinocytes in a restricted manner. Results To study the fate of HIV-1 immortalized oral keratinocytes .

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