Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: RNA silencing and HIV: A hypothesis for the etiology of the severe combined immunodeficiency induced by the virus. | Retrovirology BioMed Central Open Access Hypothesis RNA silencing and HIV A hypothesis for the etiology of the severe combined immunodeficiency induced by the virus Linda B Ludwig Address 861 Main Street East Aurora New York 14052 USA Email Linda B Ludwig - Published II September 2008 Retrovirology 2008 5 79 doi 1742-4690-5-79 Received 27 February 2008 Accepted II September 2008 This article is available from http content 5 I 79 2008 Ludwig licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A novel intrinsic HIV-I antisense gene was previously described with RNA initiating from the region of an HIV-I antisense initiator promoter element HIVaINR . The antisense RNA is exactly complementary to HIV-I sense RNA and capable of forming 400 base-pair bp duplex RNA in the region of the long terminal repeat LTR spanning the beginning portion of TAR in the repeat R region and extending through the U3 region. Duplex or double-stranded RNA of several hundred nucleotides in length is a key initiating element of RNA interference RNAi in several species. This HIVaINR antisense RNA is also capable of forming multiple stem-loop or hairpin-like secondary structures by M-fold analysis with at least one that perfectly fits the criteria for a microRNA miRNA precursor. MicroRNAs miRNAs interact in a sequence-specific manner with target messenger RNAs mRNAs to induce either cleavage of the message or impede translation. Human mRNA targets of the predicted HIVaINR antisense RNA HAA microRNAs include mRNA for the human interleukin-2 receptor gamma chain IL-2RG also called the common gamma yc receptor chain because it is an integral part of 6 receptors mediating interleukin signalling .
