Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors. | Retrovirology BioMed Central Research The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism low CD4 dependence increased fusogenicity and altered sensitivity to entry inhibitors Fiorella Rossi1 Bianca Querido1 Manideepthi Nimmagadda1 Simon Cocklin2 Sonia Navas-Martín1 and Julio Martín-García 1 Open Access Address Department of Microbiology and Immunology and Center for Molecular Virology and Neuroimmunology Institute of Molecular Medicine and Infectious Disease Drexel University College of Medicine Philadelphia PA 19102 USA and 2Department of Biochemistry and Molecular Biology Drexel University College of Medicine Philadelphia PA 19102 USA Email Fiorella Rossi - fpr23@ Bianca Querido - bquerido@ Manideepthi Nimmagadda - deepti_pharm2002@ Simon Cocklin - Sonia Navas- Martín - Julio Martín-García - Corresponding author Published 6 October 2008 Received 24 July 2008 Retrovirology 2008 5 89 doi 1742-4690-5-89 Accepted 6 October 2008 This article is available from http content 5 1 89 2008 Rossi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background HIV-1 infects macrophages and microglia in the brain and can cause neurological disorders in infected patients. We and others have shown that brain-derived envelope glycoproteins Env have lower CD4 dependence and higher avidity for CD4 than those from peripheral isolates and we have also observed increased fusogenicity and reduced sensitivity to the fusion inhibitor T-1249. Due to the genetic differences between brain and spleen env from one individual throughout gp120 and
