Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study. | Retrovirology BioMed Central Open Access Short report Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients a pilot study Yuntao Wu 1 Alyson Yoder1 Dongyang Yu1 Weifeng Wang1 Juan Liu1 Tracey Barrett2 David Wheeler2 and Karen Schlauch3 Address Department of Molecular and Microbiology George Mason University Manassas VA 20110 USA 2Clinical Alliance For Research Education - Infectious Diseases LLC Annandale VA 22003 USA and 3Department of Genetics and Genomics Boston University School of Medicine Boston MA 02118 USA Email Yuntao Wu - ywu8@ Alyson Yoder - ryoder@ Dongyang Yu - dyu2@ Weifeng Wang - wwangb@ Juan Liu - jliug@ Tracey Barrett - tbarrett@ David Wheeler - dwheel423@ Karen Schlauch - schlauch@ Corresponding author Published 17 October 2008 Received 9 September 2008 Retrovirology 2008 5 95 doi 1742-4690-5-95 Accepted 17 October 2008 This article is available from http content 5 1 95 2008 Wu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells cofilin exists largely as a phosphorylated inactive form. Previously we demonstrated that during HIV-1 infection of resting CD4 T cells the viral envelope-CXCR4 signaling activates cofilin to overcome the static cortical actin restriction. In this pilot study we have extended this in vitro observation and examined cofilin phosphorylation in resting CD4 T cells purified from the peripheral blood of HIV-1-infected .
