Báo cáo y học: " Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene. | Retrovirology BioMed Central Research Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene Alex De Marco3 4 Chiara Biancotto2 4 Anna Knezevich4 Paolo Maiuri4 Chiara Vardabasso1 4 and Alessandro Marcello 4 Address laboratory of Molecular Medicine International Centre for Genetic Engineering and Biotechnology ICGEB Padriciano 99 34012 Trieste Italy 2IFOM-IEO Milan Italy 3EMBL Heidelberg Deutschland Germany and Laboratory of Molecular Virology International Centre for Genetic Engineering and Biotechnology ICGEB Padriciano 99 34012 Trieste Italy Email Alex De Marco - Chiara Biancotto - Anna Knezevich - knezevich@ Paolo Maiuri - maiuri@ Chiara Vardabasso - vardabasso@ Alessandro Marcello - marcello@ Corresponding author Open Access Published 4 November 2008 Received 6 October 2008 Retrovirology 2008 5 98 doi 1742-4690-5-98 Accepted 4 November 2008 This article is available from http content 5 1 98 2008 De Marco et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The human immunodeficiency virus type 1 HIV-1 favors integration in active genes of host chromatin. It is believed that transcriptional interference of the viral promoter over the endogenous gene or vice versa might occur with implications in HIV-1 post-integrative transcriptional latency. Results In this work a cell line has been transduced with a HIV-based vector and selected for Tat-inducible expression. These cells were found to carry a single .