Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes. | Retrovirology BioMed Central Research MicroRNA miR-l46a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes Klemens Pichler Grit Schneider and Ralph Grassmann Open Access Address Institute of Clinical and Molecular Virology University Erlangen-Nuremberg Schlossgarten 4 Erlangen Germany Email Klemens Pichler - Grit Schneider - Ralph Grassmann - Corresponding author Published 12 November 2008 Received 2 August 2008 Retrovirology 2008 5 100 doi 1742-4690-5-100 Accepted 12 November 2008 This article is available from http content 5 1 100 2008 Pichler et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human T-lymphotropic virus type 1 HTLV-1 is the etiologic agent of a severe and fatal lymphoproliferative disease of mainly CD4 T cell origin adult T cell leukemia which develops after prolonged viral persistence. Transformation of infected cells involves HTLV-1 s oncoprotein Tax which perturbs cell cycle regulation and modulates cellular gene expression. The latter function is also a hallmark of microRNAs a rather new layer in the regulation of gene expression. Affecting . proliferation microRNAs constitute a potential target for viral interference on the way to persistence and transformation. Hence we explored the interconnections between HTLV-1 and cellular microRNAs. Results We report that several microRNAs - miRs 21 24 146a 155 and 223 - are deregulated in HTLV-1-transformed cells. They are all upregulated except for miR-223 which is downregulated. Each of those microRNAs has ties to cancer. Their .
