Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection. | Retrovirology BioMed Central Open Access Topical application of entry inhibitors as virustats to prevent sexual transmission of HIV infection Michael M Lederman 1 Robin Jump1 Heather A Pilch-Cooper1 Michael Root2 and Scott F Sieg1 Address Department of Medicine Case Western Reserve University 1100 Euclid Ave Cleveland OH 44118 USA and 2Kimmel Cancer Center Thomas Jefferson University 233 South 10th Street Philadelphia PA 19107 USA Email Michael M Lederman - MXL6@ Robin Jump - Heather A Pilch-Cooper - Michael Root - mroot@ Scott F Sieg - sfs2@ Corresponding author Published 18 December 2008 Received 14 October 2008 Accepted 18 December 2008 Retrovirology 2008 5 116 doi l742-4690-5-116 This article is available from http content 5 1 1 16 2008 Lederman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future work to develop a topical strategy to prevent HIV infection is increasingly important. This stated the track record of large scale microbicide trials has been disappointing with nonspecific inhibitors either failing to protect women from infection or even increasing HIV acquisition. Newer strategies that target directly the elements needed for viral entry into cells have shown promise in non-human primate models of HIV transmission and as these agents have not yet been broadly introduced in regions of highest HIV prevalence they are particularly attractive for prophylaxis. We review here the agents that can block HIV cellular entry and that show promise as topical strategies or virustats to prevent mucosal .
