Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals. | Retrovirology BioMed Central Research MicroRNA profile changes in human immunodeficiency virus type I HIV-1 seropositive individuals Laurent Houzetf1 Man Lung Yeungt1 Valery de Lame2 Dhara Desai2 Stephen M Smith2 and Kuan-Teh Jeang 1 Address 1Molecular Virology Section Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland 20892 USA and 2Department of Infectious Diseases Saint Michael s Medical Center Newark New Jersey 07102 USA Email Laurent Houzet - houzetl@ Man Lung Yeung - yeungm@ Valery de Lame - Dhara Desai - Stephen M Smith - SSmith1824@ Kuan-Teh Jeang - kjeang@ Corresponding author tEqual contributors Open Access Published 29 December 2008 Received 10 December 2008 Accepted 29 December 2008 Retrovirology 2008 5 118 doi l742-4690-5-118 This article is available from http content 5 1 1 18 2008 Houzet et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ MicroRNAs miRNAs play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4 T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes. Background MiRNAs are single-stranded small oligoribonucleotides of 19-25 nt in size that originate from larger RNA polymerase II RNAP II .
