Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome. | Retrovirology BioMed Central Open Access Review Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome Cheryl Bolinger and Kathleen Boris-Lawrie Address Center for Retrovirus Research Department ofVeterinary Biosciences Molecular Cellular and Developmental Biology graduate program The Ohio State University Columbus Ohio USA Email Cheryl Kathleen Boris-Lawrie - Corresponding author Published 24 January 2009 Received 8 August 2008 Retrovirology 2009 6 8 doi 1742-4690-6-8 Accepted 24 January 2009 This article is available from http content 6 1 8 2009 Bolinger and Boris-Lawrie licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Retroviruses have evolved multiple strategies to direct the synthesis of a complex proteome from a single primary transcript. Their mechanisms are modulated by a breadth of virus-host interactions which are of significant fundamental interest because they ultimately affect the efficiency of virus replication and disease pathogenesis. Motifs located within the untranslated region UTR of the retroviral RNA have established roles in transcriptional trans-activation RNA packaging and genome reverse transcription and a growing literature has revealed a necessary role of the UTR in modulating the efficiency of viral protein synthesis. Examples include a 5 UTR post-transcriptional control element PCE present in at least eight retroviruses that interacts with cellular RNA helicase A to facilitate cap-dependent polyribosome association and 3 UTR constitutive transport element CTE of .
