Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex. | Retrovirology BioMed Central Research Open Access Inhibition of HIV-I replication by P-TEFb inhibitors DRB seliciclib and flavopiridol correlates with release of free P-TEFb from the large inactive form of the complex Sebastian Biglionet1 5 Sarah A Byers11 6 Jason P Price2 Van Trung Nguyen4 Olivier Bensaude4 David H Price1 3 and Wendy Maury 1 2 Address Unterdisciplinary Molecular and Cellular Biology Program University of Iowa Iowa City IA USA 2Department of Microbiology University of Iowa Iowa City IA USA 3Department of Biochemistry University of Iowa Iowa City IA USA 4Laboratoire de Regulation de l Expression Genetique Ecole Normale Superieure Paris France 5CBR Institute for Biomedical Research Harvard Medical School Boston MA 02115 USA and 6Oregon Health Science University Department of Molecular and Medical Genetics Portland OR 97239 USA Email Sebastian Biglione - biglione@ Sarah A Byers - byerssa@ Jason P Price - jason-price@ Van Trung Nguyen - vtnguyen@ Olivier Bensaude - bensaude@ David H Price - david-price@ Wendy Maury - wendy-maury@ Corresponding author tEqual contributors Published II July 2007 Received 23 April 2007 Retrovirology 2007 4 47 doi 1742-4690-4-47 Accepted 11 July 2007 This article is available from http content 4 1 47 2007 Biglione et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The positive transcription elongation factor P-TEFb comprised of cyclin dependent kinase 9 Cdk9 and cyclin T1 T2 or K regulates the productive elongation phase of RNA polymerase II Pol II dependent transcription of cellular and integrated viral genes. P-TEFb containing cyclin T1 is recruited to
