Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Analysis of the contribution of cellular and viral RNA to the packaging of APOBEC3G into HIV-1 virions. | Retrovirology BioMed Central Research Open Access Analysis of the contribution of cellular and viral RNA to the packaging of APOBEC3G into HIV-1 virions Mohammad A Khan Ritu Goila-Gaur Sandrine Opi Eri Miyagi Hiroaki Takeuchi Sandra Kao and Klaus Strebel Address Laboratory of Molecular Microbiology Viral Biochemistry Section National Institute of Allergy and Infectious Diseases National Institutes of Health Building 4 Room 310 4 Center Drive MSC 0460 Bethesda MD 20892-0460 USA Email Mohammad A Khan - mkhan@ Ritu Goila-Gaur - rgaur@ Sandrine Opi - opi@ Eri Miyagi - emiyagi@ Hiroaki Takeuchi - htake@ Sandra Kao - skao@ Klaus Strebel - kstrebel@ Corresponding author Published 16 July 2007 Received 4 May 2007 Retrovirology 2007 4 48 doi 1742-4690-4-48 Accepted 16 July 2007 This article is available from http content 4 1 48 2007 Khan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Efficient incorporation of the cellular cytidine deaminase APOBEC3G APO3G into HIV-1 virions is necessary for its antiviral activity. Even though cellular RNAs are known to be non-specifically incorporated into virus particles we have previously found that encapsidation of APO3G into HIV-1 virions is specifically enhanced by viral genomic RNA. Intracellularly APO3G was found to form large RNA-protein complexes involving a variety of cellular RNAs. The goal of this study was to investigate the possible contribution of host RNAs recently identified in intracellular APO3G ribonucleoprotein complexes to APO3G s encapsidation into HIV-1 virions. Results Our results show that 7SL RNA a component of .
