Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells. | Retrovirology BioMed Central Open Access Endogenous TGF-P activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4 CD25- T cells Shoba Amarnath1 Li Dong2 Jun Li1 Yuntao Wu2 and WanJun Chen 1 Address 1Mucosal Immunology Unit OIIB NIDCR NIH Bethesda MD 20895 USA and 2National Center for Biodefense and Infectious Diseases Department of Molecular and Microbiology George Mason University Manassas VA 20110 USA Email Shoba Amarnath - samarnath@ Li Dong - ldong@ Jun Li - lijun@ Yuntao Wu - ywu8@ WanJun Chen - wchen@ Corresponding author Published 9 August 2007 Received 12 June 2007 Retrovirology 2007 4 57 doi 1742-4690-4-57 Accepted 9 August 2007 This article is available from http content 4 1 57 2007 Amarnath et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background CD4 CD25 T regulatory cells Tregs play an important role in regulating immune responses and in influencing human immune diseases such as HIV infection. It has been shown that human CD4 CD25 Tregs can be induced in vitro by TCR stimulation of CD4 CD25- T cells. However the mechanism remains elusive and intriguingly similar treatment of murine CD4 CD25- cells did not induce CD4 CD25 Foxp3 Tregs unless exogenous TGF-P was added during stimulation. Thus we investigated the possible role of TGF-P in the induction of human Tregs by TCR engagement. We also explored the effects of TGF-P on HIV-1 infection mediated induction of human Tregs since recent evidence has suggested that HIV-1 infection may also impact the generation of Tregs in infected patients. Results We show here that endogenous TGF-P is key to TCR induction of .
