Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Downregulation of CD94/NKG2A inhibitory receptors on cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts. | Retrovirology BioMed Central Open Access Short report Downregulation of CD94 NKG2A inhibitory receptors on CD8 T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts Mustapha Zeddou1 Souad Rahmouni 1 Arnaud Vandamme1 Nathalie Jacobs2 Frédéric Frippiat3 Philippe Leonard3 Nicole Schaaf-Lafontaine4 Dolores Vaira3 Jacques Boniver2 and Michel Moutschen1 3 Address University of Liège Laboratory of Immunology and Infectious Diseases GIGA-R Liège Belgium 2University of Liège Department of Pathology CRCE-GIGA Liège Belgium 3University of Liège Department of Infectious Diseases CHU Liège Belgium and 4University of Liège Department of Biological Haematology CHU Liège Belgium Email Mustapha Zeddou - mzeddou@ Souad Rahmouni - srahmouni@ Arnaud Vandamme - Nathalie Jacobs - Frédéric Frippiat - Philippe Leonard - Nicole Schaaf-Lafontaine - Dolores Vaira - dvaira@ Jacques Boniver - Michel Moutschen - Corresponding author Published 10 October 2007 Received 2 April 2007 Accepted 10 October 2007 Retrovirology 2007 4 72 doi 1742-4690-4-72 This article is available from http contentM 1 72 2007 Zeddou et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The CD94 NKG2A heterodimer is a natural killer receptor NKR which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small fraction of activated CD8 T lymphocytes. Abnormal upregulation of the CD94 NKG2A inhibitory
