Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions?. | Retrovirology BioMed Central Commentary Open Access Small non-coding RNAs mammalian cells and viruses regulatory interactions Man Lung Yeung1 Monsef Benkirane2 and Kuan-Teh Jeang 1 Address 1Molecular Virology Section Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland 20892-0460 USA and 2Insitute de Genetique Humaine Montpellier France Email Man LungYeung - yeungm@ MonsefBenkirane - Kuan- Teh Jeang - KJEANG@ Corresponding author Published 15 October 2007 Received 10 October 2007 Accepted 15 October 2007 Retrovirology 2007 4 74 doi 1742-4690-4-74 This article is available from http content 4 1 74 2007 Yeung et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Recent findings suggest that mammalian cells can use small non-coding RNAs ncRNA to regulate physiological viral infections. Here we comment on several lines of evidence that support this concept. We discuss how viruses may in turn protect suppress evade modulate or adapt to the host cell s ncRNA regulatory schema. Small RNAs interference and activation Plant and animal genomes have thousands of genes that encode non-protein-coding nc RNAs. While recent attention has focused significantly on small interfering RNAs siRNAs and micro RNAs miRNAs ncRNAs also include rRNA tRNA small nuclear sn RNA small nucleolar sno RNAs and some of the lesser-known RNAs such as vault RNAs Y RNAs rasi-RNAs and piRNAs reviewed in 1 . It is now recognized that only 2 of the human genome encodes for protein-coding RNAs while 60 to 70 of our DNA is transcribed into ncRNAs 2 3 . Hence despite accumulating research on
