Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export. | Retrovirology BioMed Central Research Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export Michael L Gatza Tajhal Dayaram and Susan J Marriott Open Access Address Department of Molecular Virology and Microbiology Interdepartmental Program in Cell and Molecular Biology Baylor College of Medicine Houston Texas 77030 USA Email Michael L Gatza - Tajhal Dayaram - dayaram@ Susan J Marriott - susanm@ Corresponding author Published 14 December 2007 Received 3 July 2007 Accepted 14 December 2007 Retrovirology 2007 4 95 doi 1742-4690-4-95 This article is available from http content 4 1 95 2007 Gatza et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The HTLV-I oncoprotein Tax is a pleiotropic protein whose activity is partially regulated by its ability to interact with and perturb the functions of numerous cellular proteins. Tax is predominantly a nuclear protein that localizes to nuclear foci known as Tax Speckled Structures TSS . We recently reported that the localization of Tax and its interactions with cellular proteins are altered in response to various forms of genotoxic and cellular stress. The level of cytoplasmic Tax increases in response to stress and this relocalization depends upon the interaction of Tax with CRM1. Cellular pathways and signals that regulate the subcellular localization of Tax remain to be determined. However post-translational modifications including sumoylation and ubiquitination are known to influence the subcellular localization of Tax and its interactions with cellular proteins. The sumoylated form of Tax exists predominantly in the nucleus while .
