Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Preclinical evaluation of lime juice as a topical microbicide candidate. | Retrovirology BioMed Central Research Preclinical evaluation of lime juice as a topical microbicide candidate Patricia S Fletcher1 Sarah J Harman1 Adrienne R Boothe2 Gustavo F Doncel2 and Robin J Shattock 1 Open Access Address 1St George s University of London UK and 2CONRAD Eastern Virginia Medical School USA Email Patricia S Fletcher - pfletche@ Sarah J Harman - sharman@ Adrienne R Boothe - BootheAR@ Gustavo F Doncel - DoncelGF@ Robin J Shattock - shattock@ Corresponding author Published II January 2008 Received 18 October 2007 Accepted 1 1 January 2008 Retrovirology 2008 5 3 doi 1742-4690-5-3 p This article is available from http content 5 1 3 2008 Fletcher et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The continued growth of the global HIV epidemic highlights the urgent need to develop novel prevention strategies to reduce HIV transmission. The development of topical microbicides is likely to take a number of years before such a product would be widely available. This has resulted in a call for the rapid introduction of simpler vaginal intervention strategies in the interim period. One suggested practice would be vaginal douching with natural products including lime or lemon juice. Here we present a comprehensive preclinical evaluation of lime juice LiJ as a potential intervention strategy against HIV. Results Pre-treatment of HIV with LiJ demonstrated direct virucidal activity with 10 juice inactivating the virus within 5 minutes. However this activity was significantly reduced in the presence of seminal plasma where inactivation .
