Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Pvt1-encoded microRNAs in oncogenesis. | Retrovirology BioMed Central Open Access Pvt -encoded microRNAs in oncogenesis Gabriele B Beck-EngeseG1 Amy M Lumt2 Konrad Huppi3 Natasha J Caplen3 Bruce B Wang2 and Matthias Wabl 1 Address Department of Microbiology and Immunology University of California San Francisco CA 94143-0414 USA 2Picobella . 863 Mitten Road Suite 101 Burlingame CA 94010 USA and 3Gene Silencing Section Genetics Branch Center Cancer Research National Cancer Institute Bethesda MD 20892 USA Email Gabriele B Beck-Engeser - Amy M Lum - amy@ Konrad Huppi - huppi@ Natasha J Caplen - ncaplen@ Bruce B Wang - bruce@ Matthias Wabl - mutator@ Corresponding author tEqual contributors Published 14 January 2008 Received 29 October 2007 Accepted 14 January 2008 Retrovirology 2008 5 4 doi l742-4690-5-4 p This article is available from http content 5 1 4 2008 Beck-Engeser et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The functional significance of the Pvtl locus in the oncogenesis of Burkitt s lymphoma and plasmacytomas has remained a puzzle. In these tumors Pvtl is the site of reciprocal translocations to immunoglobulin loci. Although the locus encodes a number of alternative transcripts no protein or regulatory RNA products were found. The recent identification of noncoding microRNAs encoded within the PVTI region has suggested a regulatory role for this locus. Results The mouse Pvtl locus encodes several microRNAs. In mouse T cell lymphomas induced by retroviral insertions into the locus the Pvtl transcripts and at least one of their .
